Santa Fe Cafe

Restaurants in Mid-Island, Hilton Head Island, SC

Mid-Island

Santa Fe Cafe is Hilton Head Island's beloved Southwestern dining destination, bringing the bold, sun-drenched flavors of New Mexico and the American Southwest to the South Carolina coast. Open since 1988, the restaurant has earned a devoted following for its creative, chile-forward cooking — from house-made green and red chile sauces and blue corn enchiladas to slow-braised meats, fresh guacamole prepared tableside, and a legendary margarita program featuring premium tequilas and fresh-squeezed citrus. The warm, adobe-inspired interior is filled with authentic Southwestern art and handcrafted furnishings that transport guests far from the Lowcountry. The kitchen sources quality ingredients and prepares everything from scratch, resulting in dishes that are deeply flavorful and genuinely satisfying. Santa Fe Cafe is a Hilton Head institution — a restaurant where the food is made with passion, the atmosphere is warm and welcoming, and every visit feels like a mini-vacation to the American Southwest.

Address

807 William Hilton Parkway, Suite 700, Hilton Head Island, SC 29928

Neighborhood

Mid-Island

Phone

(843) 785-3838

Website

www.santafehhi.com

Details last verified September 2026. Hours, pricing, and availability change — confirm directly with the business before visiting.