May River Grill

Restaurants in Bluffton, Bluffton, SC

Bluffton

May River Grill is a relaxed Bluffton restaurant on May River Road that channels the easy, unhurried spirit of life along one of the Lowcountry's most scenic waterways. The May River — known for its oyster beds, tidal marshes, and the kind of slow-moving beauty that defines the Bluffton character — gives the restaurant its name and its sensibility. The menu has a Southern soul: fresh local seafood, grilled proteins, Lowcountry-inspired sides, and daily specials that reflect what's in season and what came in fresh. The kitchen doesn't overcomplicate things, letting quality ingredients and honest cooking do the work rather than elaborate preparations or trendy technique. The setting is casual and comfortable, with an atmosphere that suits a long lunch as easily as a family dinner. For Bluffton residents and visitors who want a satisfying, genuinely local meal without the pretense of a fine dining room, May River Grill is a reliable and welcoming choice. Call (843) 757-4600 or visit mayrivergrill.com for current hours and reservations.

Address

1263 May River Rd Unit D, Bluffton, SC 29910

Neighborhood

Bluffton

Phone

(843) 757-4600

Website

mayrivergrill.com

Details last verified September 2026. Hours, pricing, and availability change — confirm directly with the business before visiting.